These findings indicate that the efficacy of antibiotic treatment in polymicrobial infection is determined at the community level, with interspecies interaction playing an important and previously unappreciated role. aeruginosa significantly alters the outcome of S. aureus coinfection to demonstrate that the presence of P.
aeruginosa clinical isolates, with dramatic repercussions for S. aureus susceptibility to antibiotic killing, and furthermore demonstrate that these compounds are produced at varying levels in P. We identify the exoproducts responsible for altering S. aeruginosa can antagonize or potentiate the efficacy of multiple classes of antibiotics against S. aeruginosa, can completely transform the antibiotic susceptibility profile of S. Here we show that a single interspecies interaction between 2 human pathogens, S. While many studies have considered the impacts of genetically encoded mechanisms of resistance, nongenetic determinants of antibiotic susceptibility during infection remain poorly understood. Consideration of these interactions will improve the treatment of polymicrobial infections.Īccurate prediction of antimicrobial efficacy is essential for successful treatment of a bacterial infection. These findings demonstrate that antibiotic susceptibility is complex and dependent not only upon the genotype of the pathogen being targeted, but also on interactions with other microorganisms in the infection environment. aureus mouse burn infection is potentiated by the presence of a LasA-producing P. Furthermore, we demonstrate that vancomycin treatment of a S. We find that the production of each of these factors varies between clinical isolates and corresponds to the capacity of each isolate to alter S. aureus through respiratory inhibition and reduction of cellular ATP. aureus by vancomycin, rhamnolipids facilitate proton-motive force-independent tobramycin uptake, and 2-heptyl-4-hydroxyquinoline N-oxide (HQNO) induces multidrug tolerance in S. aeruginosa LasA endopeptidase potentiates lysis of S.
aureus susceptibility to bactericidal antibiotics in a variable, strain-dependent manner and further identify 3 independent interactions responsible for antagonizing or potentiating antibiotic activity against S. aeruginosa burn wound and cystic fibrosis (CF) lung isolates to demonstrate that P.
aureus antibiotic susceptibility remains poorly understood. Currently, the impact of interspecies interaction on S. Chronic coinfections of Staphylococcus aureus and Pseudomonas aeruginosa frequently fail to respond to antibiotic treatment, leading to significant patient morbidity and mortality.
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